Fungi and animals may share a common ancestor to nuclear receptors
نویسندگان
چکیده
منابع مشابه
Fungi and animals may share a common ancestor to nuclear receptors.
Nuclear receptors (NRs) are a large family of transcription factors. One hallmark of this family is the ligand-binding domain (LBD), for its primary sequence, structure, and regulatory function. To date, NRs have been found exclusively in animals and sponges, which has led to the generally accepted notion that they arose with them. We have overcome the limitations of primary sequence searches b...
متن کاملCommon allergenic pollens, fungi, animals, and arthropods.
Certain plants produce prodigious amounts of pollen. A single plant can produce 1 million to several million pollen grains in a day. In general, brightly colored flowering plants are of little clinical importance in inhalant allergy because their pollen is designed to be carried by insects (entomophilous) rather than by the wind (anemophilous). Many grasses, trees and weeds produce sufficient q...
متن کاملLRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.
Leucine-rich repeat-containing 8 (LRRC8) proteins are composed of four transmembrane helices and 17 leucine-rich repeats (LRR). Although LRRC8 proteins have been associated with important processes, like maturation of B cells or adipocyte differentiation, their biology and molecular function are largely unknown. We found that LRRC8 proteins originated from the combination of a pannexin and an L...
متن کاملAnimals and Fungi: Common Origin, but Independent Approaches to Multicellularity
Motivation: Numerous recent publications have demonstrated convincingly that the most effective approach to understanding the origin of the human genome is comparative animal genomics (e.g., (1-3)). Similarly, to understand the origin of multicellularity and animal-specific gene families that are relevant to human development, health and complex diseases, we need to trace back these features to...
متن کاملPaired Ig-like receptor homologs in birds and mammals share a common ancestor with mammalian Fc receptors.
Paired Ig-like receptors (PIR) that can reciprocally modulate cellular activation have been described in mammals. In the present study, we searched expressed sequence tag databases for PIR relatives to identify chicken expressed sequence tags predictive of approximately 25% amino acid identity to mouse PIR. Rapid amplification of cDNA ends (RACE)-PCR extension of expressed sequence-tag sequence...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2006
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0510080103